Subchronic oral administration of crude khat extract (Catha edulis forsk) induces schizophernic-like symptoms in mice
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چکیده
منابع مشابه
Subchronic oral administration of crude khat extract (Catha edulis forsk) induces schizophernic-like symptoms in mice
BACKGROUND Chewing fresh leaves of the khat plant (Catha edulis forsk) is a deep rooted and widespread habit in East Africa and the Middle East. Although a body of knowledge exists about the adverse effects of khat on health, data are sparse with regard to the consequences of long-term khat chewing in resulting schizophrenic like symptoms. METHODS A crude extract of khat at different doses (1...
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BACKGROUND Although various studies have been conducted to shed light on the pharmacological actions of khat, little or no data are available regarding khat's effect on the renal redox system. The aim of this study was therefore to investigate the potential of nephrotoxicity associated with khat exposure in rats. METHODS Sprague Dawely rats were randomly assigned into eight experimental group...
متن کاملCatha edulis Forsk. (Khat): Evaluation of its Antidepressant-like Activity
BACKGROUND Catha edulis Forsk. (Khat) is traditionally used for treating various disorders. Nevertheless there are no reports of any scientific assessment of its psychopharmacological properties. OBJECTIVE Therefore, the current study was designed to evaluate the antidepressant-like activity of Khat ethanolic extract using established animal models of depression and stress. MATERIALS AND ME...
متن کاملGenotoxic effect of Catha edulis (khat) crude extract after sub-chronic administration in rats.
The aim of this study was to evaluate the genotoxic effects of a crude extract of khat (Catha edulis, Forsk) leaves in rats. Two groups were fed khat crude extract, 1000 and 2000mg/kg body weight, for 90 days and were compared with a control group. The alkaline (pH>13) version of comet assay was used in this study. However, no previous published work has been undertaken and showed the effect of...
متن کاملAssessment of khat (Catha edulis Forsk) 1. Substance Identification
F. WHO Review History: The WHO Expert Committee on Drug Dependence (ECDD) and other UN bodies reviewed khat at earlier occasions. The Advisory Committee on the Traffic in Opium and Other Dangerous Drugs of the League of Nations discussed on the subject in 1933, but no action was taken. On request of the Commission on Narcotics Drugs (CND), the Expert Committee on Addiction-Producing Drugs (as t...
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ژورنال
عنوان ژورنال: BMC Complementary and Alternative Medicine
سال: 2016
ISSN: 1472-6882
DOI: 10.1186/s12906-016-1145-6